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Question 1 of 9
1. Question
When evaluating options for vi. Colony-Stimulating Factor Administration, what criteria should take precedence? A patient with Non-Hodgkin Lymphoma is undergoing a dose-dense chemotherapy regimen that carries a high risk for febrile neutropenia. The oncologist has prescribed prophylactic Granulocyte Colony-Stimulating Factor (G-CSF) to support the patient’s myeloid recovery. When reviewing the clinical documentation for coding and compliance, which factor is most critical regarding the timing of the CSF administration in relation to the cytotoxic treatment?
Correct
Correct: According to clinical guidelines and coding standards for Colony-Stimulating Factors (CSFs), G-CSF (such as filgrastim or pegfilgrastim) should not be administered in the period between 24 hours before and 24 hours after the administration of cytotoxic chemotherapy. This is because CSFs stimulate the proliferation of hematopoietic progenitor cells; if chemotherapy is given while these cells are rapidly dividing, they become more susceptible to the cytotoxic effects of the drugs, potentially worsening myelosuppression rather than mitigating it.
Incorrect: Administering CSF concurrently with chemotherapy is contraindicated because it increases the sensitivity of myeloid cells to the chemotherapy. Waiting for the ANC to reach a nadir before administration describes a reactive or therapeutic use rather than the prophylactic use indicated for high-risk dose-dense regimens. Administering CSF within 12 hours before chemotherapy is also incorrect, as the 24-hour window must be respected to ensure the stimulated cells are not destroyed by the upcoming treatment.
Takeaway: To ensure patient safety and therapeutic efficacy, colony-stimulating factors must be administered at least 24 hours after the completion of a chemotherapy dose.
Incorrect
Correct: According to clinical guidelines and coding standards for Colony-Stimulating Factors (CSFs), G-CSF (such as filgrastim or pegfilgrastim) should not be administered in the period between 24 hours before and 24 hours after the administration of cytotoxic chemotherapy. This is because CSFs stimulate the proliferation of hematopoietic progenitor cells; if chemotherapy is given while these cells are rapidly dividing, they become more susceptible to the cytotoxic effects of the drugs, potentially worsening myelosuppression rather than mitigating it.
Incorrect: Administering CSF concurrently with chemotherapy is contraindicated because it increases the sensitivity of myeloid cells to the chemotherapy. Waiting for the ANC to reach a nadir before administration describes a reactive or therapeutic use rather than the prophylactic use indicated for high-risk dose-dense regimens. Administering CSF within 12 hours before chemotherapy is also incorrect, as the 24-hour window must be respected to ensure the stimulated cells are not destroyed by the upcoming treatment.
Takeaway: To ensure patient safety and therapeutic efficacy, colony-stimulating factors must be administered at least 24 hours after the completion of a chemotherapy dose.
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Question 2 of 9
2. Question
The monitoring system at an insurer has flagged an anomaly related to 3. Coding Oncology Procedures and Services during risk appetite review. Investigation reveals that a high volume of claims for bone marrow aspiration and biopsy (CPT 38222) are being submitted with modifier 59 when performed on the same date as chemotherapy administration. A review of 50 patient charts over the last quarter shows that while both procedures were performed, the documentation for the bone marrow procedure often lacks a distinct clinical indication or evidence of a separate anatomic site from the primary malignancy being treated. Which of the following represents the most appropriate internal audit recommendation to ensure compliance with National Correct Coding Initiative (NCCI) edits and CPT guidelines?
Correct
Correct: CPT 38222 (Diagnostic bone marrow; aspiration and biopsy) and chemotherapy administration are subject to NCCI edits. To bypass these edits using modifier 59 (or the more specific X{EPSU} modifiers), the documentation must clearly support that the procedure was performed at a separate anatomic site, through a separate incision, or during a distinct session. An internal audit recommendation should focus on ensuring that the clinical documentation justifies the use of the modifier to prevent ‘unbundling’ and potential fraud or abuse charges.
Incorrect: The suggestion to automatically append modifier 51 is incorrect because modifier 51 is used for multiple procedures but does not bypass NCCI edits, and ‘automatic’ appending without clinical review is a significant compliance risk. Using modifier 25 is incorrect because that modifier is reserved for Evaluation and Management (E/M) services, not for procedural codes like chemotherapy administration. Suggesting that the services can never be reported together is incorrect because NCCI edits allow for both services to be billed if they are truly distinct and documented appropriately; a blanket policy of non-reporting leads to inaccurate data and lost legitimate revenue.
Takeaway: Accurate oncology coding requires clinical documentation that justifies the use of modifiers to bypass NCCI edits by demonstrating distinct procedural sites or purposes.
Incorrect
Correct: CPT 38222 (Diagnostic bone marrow; aspiration and biopsy) and chemotherapy administration are subject to NCCI edits. To bypass these edits using modifier 59 (or the more specific X{EPSU} modifiers), the documentation must clearly support that the procedure was performed at a separate anatomic site, through a separate incision, or during a distinct session. An internal audit recommendation should focus on ensuring that the clinical documentation justifies the use of the modifier to prevent ‘unbundling’ and potential fraud or abuse charges.
Incorrect: The suggestion to automatically append modifier 51 is incorrect because modifier 51 is used for multiple procedures but does not bypass NCCI edits, and ‘automatic’ appending without clinical review is a significant compliance risk. Using modifier 25 is incorrect because that modifier is reserved for Evaluation and Management (E/M) services, not for procedural codes like chemotherapy administration. Suggesting that the services can never be reported together is incorrect because NCCI edits allow for both services to be billed if they are truly distinct and documented appropriately; a blanket policy of non-reporting leads to inaccurate data and lost legitimate revenue.
Takeaway: Accurate oncology coding requires clinical documentation that justifies the use of modifiers to bypass NCCI edits by demonstrating distinct procedural sites or purposes.
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Question 3 of 9
3. Question
The quality assurance team at an audit firm identified a finding related to d. Port-a-Cath Insertion/Removal as part of transaction monitoring. The assessment reveals that several claims for the removal of a tunneled central venous access device (CPT 36590) were submitted alongside the insertion of a new tunneled port (CPT 36561) during the same operative session. A review of the medical records from the past six months indicates that the original device was removed due to a catheter fracture, and the new device was placed through the same venous access point. Based on CPT coding conventions and National Correct Coding Initiative (NCCI) guidelines, what is the primary risk identified in this audit finding?
Correct
Correct: According to CPT guidelines and NCCI edits, when a central venous access device is removed and a new one is inserted through the same venous access site during the same session, the removal is not separately reportable. The work of removing the old device is considered an integral part of the replacement process. Reporting both CPT 36590 and 36561 in this context constitutes unbundling, leading to an overpayment risk.
Incorrect: The use of modifier 52 is incorrect because the removal is not a ‘reduced’ service but rather a bundled component of the replacement. While documenting medical necessity and using appropriate complication codes is important for clinical accuracy, the primary compliance risk in the scenario described is the billing of two codes that are bundled by NCCI edits. Using a ‘re-evaluation’ code is not a standard CPT convention for port replacements; the issue is specifically the bundling of the removal (36590) into the replacement/insertion code.
Takeaway: When replacing a Port-a-Cath through the same access site, the removal of the old device is bundled into the code for the insertion of the new device.
Incorrect
Correct: According to CPT guidelines and NCCI edits, when a central venous access device is removed and a new one is inserted through the same venous access site during the same session, the removal is not separately reportable. The work of removing the old device is considered an integral part of the replacement process. Reporting both CPT 36590 and 36561 in this context constitutes unbundling, leading to an overpayment risk.
Incorrect: The use of modifier 52 is incorrect because the removal is not a ‘reduced’ service but rather a bundled component of the replacement. While documenting medical necessity and using appropriate complication codes is important for clinical accuracy, the primary compliance risk in the scenario described is the billing of two codes that are bundled by NCCI edits. Using a ‘re-evaluation’ code is not a standard CPT convention for port replacements; the issue is specifically the bundling of the removal (36590) into the replacement/insertion code.
Takeaway: When replacing a Port-a-Cath through the same access site, the removal of the old device is bundled into the code for the insertion of the new device.
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Question 4 of 9
4. Question
How can the inherent risks in c. Ambulance Services be most effectively addressed? An internal compliance auditor at a large oncology center is evaluating the risk of Medicare recoupment related to non-emergency ambulance transports for patients undergoing intensive chemotherapy. The auditor notes that many patients are transported from skilled nursing facilities for outpatient treatments. To ensure compliance with medical necessity requirements and prevent fraudulent billing, which control should the auditor recommend as the primary safeguard?
Correct
Correct: For non-emergency ambulance services, particularly for oncology patients, the primary compliance risk is medical necessity. Medicare and other payers require that the patient’s condition be such that any other form of transportation (like a wheelchair van or private car) would be medically contraindicated. A valid Physician Certification Statement (PCS) is a regulatory requirement for scheduled non-emergency transports, and clinical documentation must support the ‘bed-confined’ status or other medical reasons why an ambulance is the only safe option.
Incorrect: Matching modifiers and mileage is a basic billing check but does not address the underlying risk of whether the transport was medically necessary in the first place. Billing all patients with catheters as Specialty Care Transport (SCT) constitutes upcoding and potential fraud, as SCT is reserved for critically injured or ill patients requiring a level of care beyond the scope of a paramedic. Reviewing provider licensure is a standard administrative control but does not mitigate the specific risk of medical necessity denials or recoupment.
Takeaway: The most effective control for ambulance service risks is ensuring clinical documentation and physician certification explicitly justify the medical necessity of the transport mode.
Incorrect
Correct: For non-emergency ambulance services, particularly for oncology patients, the primary compliance risk is medical necessity. Medicare and other payers require that the patient’s condition be such that any other form of transportation (like a wheelchair van or private car) would be medically contraindicated. A valid Physician Certification Statement (PCS) is a regulatory requirement for scheduled non-emergency transports, and clinical documentation must support the ‘bed-confined’ status or other medical reasons why an ambulance is the only safe option.
Incorrect: Matching modifiers and mileage is a basic billing check but does not address the underlying risk of whether the transport was medically necessary in the first place. Billing all patients with catheters as Specialty Care Transport (SCT) constitutes upcoding and potential fraud, as SCT is reserved for critically injured or ill patients requiring a level of care beyond the scope of a paramedic. Reviewing provider licensure is a standard administrative control but does not mitigate the specific risk of medical necessity denials or recoupment.
Takeaway: The most effective control for ambulance service risks is ensuring clinical documentation and physician certification explicitly justify the medical necessity of the transport mode.
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Question 5 of 9
5. Question
How do different methodologies for v. Endoscopic Procedures (biopsies during endoscopy) compare in terms of effectiveness? When evaluating a patient with suspected mediastinal lymphadenopathy potentially indicative of lymphoma or metastatic spread from a primary lung malignancy, the choice between Fine Needle Aspiration (FNA) and Fine Needle Biopsy (FNB) during an Endoscopic Ultrasound (EUS) is critical for diagnostic yield.
Correct
Correct: In the context of oncology and hematology, the methodology of the biopsy is driven by the diagnostic requirement. Fine Needle Biopsy (FNB) needles are designed to obtain a core of tissue that preserves the histological architecture. This is particularly effective and often necessary for the accurate subtyping of lymphomas (such as distinguishing between various Non-Hodgkin subtypes) and the immunohistochemical staining required for many oncologic diagnoses, whereas Fine Needle Aspiration (FNA) primarily collects individual cells for cytological examination.
Incorrect: FNA is not the exclusive recommendation for lymphoma; in fact, the lack of architectural detail in FNA can often lead to inconclusive results for lymphoma subtyping. Brush cytology is a superficial sampling technique and is ineffective for submucosal lesions or deep tissue layers. Jumbo forceps actually provide a larger tissue volume than cold forceps and are often preferred when deeper or more substantial mucosal samples are needed, contrary to the claim that cold forceps allow for deeper penetration.
Takeaway: Fine Needle Biopsy (FNB) is superior to Fine Needle Aspiration (FNA) when preserved tissue architecture is required for complex oncologic diagnoses like lymphoma subtyping.
Incorrect
Correct: In the context of oncology and hematology, the methodology of the biopsy is driven by the diagnostic requirement. Fine Needle Biopsy (FNB) needles are designed to obtain a core of tissue that preserves the histological architecture. This is particularly effective and often necessary for the accurate subtyping of lymphomas (such as distinguishing between various Non-Hodgkin subtypes) and the immunohistochemical staining required for many oncologic diagnoses, whereas Fine Needle Aspiration (FNA) primarily collects individual cells for cytological examination.
Incorrect: FNA is not the exclusive recommendation for lymphoma; in fact, the lack of architectural detail in FNA can often lead to inconclusive results for lymphoma subtyping. Brush cytology is a superficial sampling technique and is ineffective for submucosal lesions or deep tissue layers. Jumbo forceps actually provide a larger tissue volume than cold forceps and are often preferred when deeper or more substantial mucosal samples are needed, contrary to the claim that cold forceps allow for deeper penetration.
Takeaway: Fine Needle Biopsy (FNB) is superior to Fine Needle Aspiration (FNA) when preserved tissue architecture is required for complex oncologic diagnoses like lymphoma subtyping.
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Question 6 of 9
6. Question
How should 1. Medicare Guidelines (e.g., National Coverage Determinations – NCDs, Local Coverage Determinations – LCDs) be correctly understood for Certified Hematology and Oncology Coder (CHONC) when determining the medical necessity and documentation requirements for Erythropoiesis-Stimulating Agents (ESAs) in patients with non-myeloid malignancies?
Correct
Correct: National Coverage Determinations (NCDs) are developed by CMS to describe the circumstances under which Medicare will pay for items or services nationwide. They are the highest level of authority. Local Coverage Determinations (LCDs) are developed by individual Medicare Administrative Contractors (MACs) to provide coverage guidance for their specific jurisdictions when no NCD exists or to supplement an NCD with additional details. An LCD can never be less restrictive than an NCD, nor can it contradict a national policy.
Incorrect: The claim that LCDs take precedence over NCDs is incorrect because national policy always overrides local policy. The suggestion that providers must wait for a CMS ruling in the absence of an NCD is false; MACs have the authority to create LCDs to address coverage in the absence of national guidance. Finally, NCDs and LCDs are not merely advisory; they are mandatory requirements that define medical necessity, and failure to adhere to the specified ICD-10-CM linkages or clinical thresholds (such as hemoglobin levels for ESAs) will result in claim denials.
Takeaway: National Coverage Determinations (NCDs) provide the baseline for nationwide coverage, while Local Coverage Determinations (LCDs) fill gaps for specific jurisdictions without contradicting national standards.
Incorrect
Correct: National Coverage Determinations (NCDs) are developed by CMS to describe the circumstances under which Medicare will pay for items or services nationwide. They are the highest level of authority. Local Coverage Determinations (LCDs) are developed by individual Medicare Administrative Contractors (MACs) to provide coverage guidance for their specific jurisdictions when no NCD exists or to supplement an NCD with additional details. An LCD can never be less restrictive than an NCD, nor can it contradict a national policy.
Incorrect: The claim that LCDs take precedence over NCDs is incorrect because national policy always overrides local policy. The suggestion that providers must wait for a CMS ruling in the absence of an NCD is false; MACs have the authority to create LCDs to address coverage in the absence of national guidance. Finally, NCDs and LCDs are not merely advisory; they are mandatory requirements that define medical necessity, and failure to adhere to the specified ICD-10-CM linkages or clinical thresholds (such as hemoglobin levels for ESAs) will result in claim denials.
Takeaway: National Coverage Determinations (NCDs) provide the baseline for nationwide coverage, while Local Coverage Determinations (LCDs) fill gaps for specific jurisdictions without contradicting national standards.
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Question 7 of 9
7. Question
A new business initiative at a private bank requires guidance on 1. Application of HCPCS Level II Codes in Hematology and Oncology as part of incident response. The proposal raises questions about the financial integrity of a healthcare portfolio company specializing in leukemia treatments. An internal audit of the facility’s claims reveals that for drugs like Rituximab (J9312), the billing department is only reporting the units actually administered, despite using single-dose vials where waste is inevitable. To ensure compliance with HCPCS Level II reporting requirements and CMS guidelines, which recommendation is most appropriate?
Correct
Correct: According to CMS and HCPCS Level II guidelines, when a drug is supplied in a single-dose vial and a portion is discarded, the JW modifier must be used to report the wasted amount on a separate line item. This ensures that the provider is reimbursed for the entire vial while maintaining an accurate record of the amount actually administered to the patient. The documentation in the medical record must support both the administered and the discarded amounts.
Incorrect: Using an unclassified drug code like J3490 is incorrect when a specific HCPCS code (like J9312 for Rituximab) exists. The JZ modifier is specifically used to certify that no drug was wasted, which would be inaccurate in this scenario where waste occurred. Consolidating waste from multiple patients into a single claim is a violation of billing standards, as drug administration and waste must be reported on a per-patient, per-encounter basis to maintain the integrity of the patient’s medical and billing record.
Takeaway: Proper HCPCS Level II reporting for oncology drugs requires the use of the JW modifier for discarded amounts from single-dose vials to ensure compliance and accurate reimbursement.
Incorrect
Correct: According to CMS and HCPCS Level II guidelines, when a drug is supplied in a single-dose vial and a portion is discarded, the JW modifier must be used to report the wasted amount on a separate line item. This ensures that the provider is reimbursed for the entire vial while maintaining an accurate record of the amount actually administered to the patient. The documentation in the medical record must support both the administered and the discarded amounts.
Incorrect: Using an unclassified drug code like J3490 is incorrect when a specific HCPCS code (like J9312 for Rituximab) exists. The JZ modifier is specifically used to certify that no drug was wasted, which would be inaccurate in this scenario where waste occurred. Consolidating waste from multiple patients into a single claim is a violation of billing standards, as drug administration and waste must be reported on a per-patient, per-encounter basis to maintain the integrity of the patient’s medical and billing record.
Takeaway: Proper HCPCS Level II reporting for oncology drugs requires the use of the JW modifier for discarded amounts from single-dose vials to ensure compliance and accurate reimbursement.
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Question 8 of 9
8. Question
The operations team at an insurer has encountered an exception involving ii. Resections (partial, total) during whistleblowing. They report that a specialized oncology clinic is frequently billing for total splenectomies in cases where the operative notes describe a subtotal or partial removal intended to preserve splenic immune function in patients with chronic hematologic disorders. To resolve this exception, the auditor must identify the specific documentation that distinguishes a total resection from a partial resection. Which of the following is the primary requirement for coding a total resection in this scenario?
Correct
Correct: In oncology and hematology coding, a total resection (such as a total splenectomy) is defined by the complete anatomical removal of the organ. This is clinically and procedurally evidenced by the ligation of the primary vascular supply (the main artery and vein) and the removal of the entire structure. If any portion of the organ is left behind to maintain physiological function, it must be coded as a partial resection, regardless of the complexity of the case.
Incorrect: The weight of the tissue is a pathological measurement that varies by patient and disease state and does not define the surgical scope. The diagnosis (malignant vs. benign) may influence the medical necessity or the specific code set used, but it does not dictate whether a resection is classified as partial or total. Intraoperative time is a factor for using modifiers related to increased procedural services but does not change the fundamental definition of the resection type performed.
Takeaway: A total resection is defined by the complete anatomical removal of the organ and its primary vascular supply, whereas a partial resection involves leaving functional tissue behind.
Incorrect
Correct: In oncology and hematology coding, a total resection (such as a total splenectomy) is defined by the complete anatomical removal of the organ. This is clinically and procedurally evidenced by the ligation of the primary vascular supply (the main artery and vein) and the removal of the entire structure. If any portion of the organ is left behind to maintain physiological function, it must be coded as a partial resection, regardless of the complexity of the case.
Incorrect: The weight of the tissue is a pathological measurement that varies by patient and disease state and does not define the surgical scope. The diagnosis (malignant vs. benign) may influence the medical necessity or the specific code set used, but it does not dictate whether a resection is classified as partial or total. Intraoperative time is a factor for using modifiers related to increased procedural services but does not change the fundamental definition of the resection type performed.
Takeaway: A total resection is defined by the complete anatomical removal of the organ and its primary vascular supply, whereas a partial resection involves leaving functional tissue behind.
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Question 9 of 9
9. Question
A transaction monitoring alert at an insurer has triggered regarding v. Endoscopic Procedures (biopsies during endoscopy) during onboarding. The alert details show that a claim was submitted for a patient with suspected extranodal Marginal Zone Lymphoma of the stomach. During an esophagogastroduodenoscopy (EGD), the physician performed three separate biopsies of the gastric antrum and two biopsies of the duodenum to evaluate the extent of disease. The provider billed for five units of the biopsy code (43239). Which of the following statements correctly identifies the coding requirement for this oncology-related procedure?
Correct
Correct: According to CPT coding guidelines for endoscopic procedures, the biopsy code (e.g., 43239) is reported only once per session, even if multiple biopsies are performed on the same or different sites during that procedure. The code descriptor specifically accounts for ‘single or multiple’ biopsies, making it inappropriate to bill multiple units or separate codes for each specimen obtained during the same EGD.
Incorrect: Reporting separate codes for each anatomical site (stomach and duodenum) is incorrect because the EGD biopsy code covers all biopsies performed during that specific entry. Using modifier -51 is inappropriate for multiple biopsies within the same endoscopic code as it is not a separate procedure. Upcoding to a surgical excision based on pathology results is a violation of coding standards; the code must reflect the procedure actually performed (biopsy), not the diagnosis or the complexity of the findings.
Takeaway: In endoscopic coding for oncology staging, a single biopsy code covers all specimens obtained during the procedure, regardless of the number of sites sampled.
Incorrect
Correct: According to CPT coding guidelines for endoscopic procedures, the biopsy code (e.g., 43239) is reported only once per session, even if multiple biopsies are performed on the same or different sites during that procedure. The code descriptor specifically accounts for ‘single or multiple’ biopsies, making it inappropriate to bill multiple units or separate codes for each specimen obtained during the same EGD.
Incorrect: Reporting separate codes for each anatomical site (stomach and duodenum) is incorrect because the EGD biopsy code covers all biopsies performed during that specific entry. Using modifier -51 is inappropriate for multiple biopsies within the same endoscopic code as it is not a separate procedure. Upcoding to a surgical excision based on pathology results is a violation of coding standards; the code must reflect the procedure actually performed (biopsy), not the diagnosis or the complexity of the findings.
Takeaway: In endoscopic coding for oncology staging, a single biopsy code covers all specimens obtained during the procedure, regardless of the number of sites sampled.